Is Alzheimer’s a form of diabetes?


From Dr. Baverman

There has been a long standing debate of whether or not insulin is produced in the brain. Researchers have recently concluded that insulin is indeed produced in different regions of the brain and is related to Alzheimer’s disease. The highest production is found in the hippocampus (the region associated with memory, learning and other cognitive functions) and in the hypothalamus (regulates emotion, and involuntary functions). One study found the brains’ of Alzheimer’s victims showed evidence of diminished production of insulin.

Dr. de la Monte and her colleagues in a review of studies suggested that Alzheimer’s disease is a neuroendocrine disorder that is similar to type 2 diabetes but more complicated. The researchers call it “brain diabetes” and propose that Alzheimer’s be called “Type 3 Diabetes”.  Their review was published in the Journal of Alzheimer’s Disorders. What is known is that depletion of neuronal insulin receptor along with other factors reproduce Alzheimer’s type degeneration supporting the theory that Alzheimer’s disease may be caused in part by neuronal insulin resistance. Ex: Brain Diabetes

It is now well known that a lot of diabetes is triggered by the deficiency in growth hormone and insulin that the brain manufactures. Read The Edge Effect to find about how to get at the root of your diabetes – through your brain. 1-888-231-PATH.  Call to get a full checkup at PATH Medical that examines the most fundamental dimension of your health – The Brain.

**de la Monte SM, Wands JR. Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer’s disease. J Alzheimer’s Dis. 2005 Feb; 7(1): 45-61. Check your Brain, Check your Health If cerebral blood flow to the brain is interrupted, brain functions cease within seconds and damage occurs. A review published in Nature Reviews Neuroscience says that cerebrovascular dysregulation is a feature not only of cerebrovascular pathologies, such as stroke, but also of neurodegenerative conditions such as Alzheimer’s disease.

Cerebrovascular dysregulation occurs following acute brain injury such as stroke and trauma and is associated with risk factors for cerebrovascular diseases such as diabetes and hypertension. This can impair the ability of the brain to maintain cerebral blood flow.

Carotid and Transcranial ultrasounds find the cerebral vascular regulation problems associated with stroke, depression and Alzheimer’s.
*Iadecola C. Neurovascular Regulation in the normal brain and in Alzheimer’s disease. Nature Reviews, Neuroscience. May 2004.

Ralph Fucetola, JD

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